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North New District
Country/Region
China (Mainland)/Chongqing
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86-023-13048470428

Anti-amnesiac Sunifiram CAS : 314728-85-3
Anti-amnesiac Sunifiram CAS : 314728-85-3
  • >= 1  Gram US $1.000
Supply Ability:
1000000 Gram/Grams per Week
Port:
Guangdong /China
Email:
Quantity:
Gram
  • Product Detils
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Quick Details
Place of Origin:
China (Mainland)
Brand Name:
CQSP
Model Number:
314728-85-3
Packaging & Delivery

foil bag, barrel or as your inquiry
Product Description

Anti-amnesiac Sunifiram CAS : 314728-85-3

Basic Info.


Name:Sunifiram

CAS : 314728-85-3

Sunifiram Purity: 99%

Molecular Formula: C12H14N2O2

Molecular Weight: 246.30

Boiling Point: ° C at 760 mmHg

Appearance: White crystal powder

Usage: For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs, Senile Dementia, Acetylcholine Release Enhancers.

Reference FOB Price:$1/g

MOQ:10g


Production Capacity:5000kg/month


Shelf life:2 years

More details pls contact:Whatapp:86 13048470428  

Skype/E-mail : summer at chembj.com


Description of Sunifiram

 

This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.


Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).


This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation.Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.


Application of Sunifiram:

 

For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs, Senile Dementia, Acetylcholine Release Enhancers.


Sunifiram (DM-235) is a synthetic derivative of Piracetam, although due to breaking the pyrrolidone backbone it is no longer in the Racetam class of drugs (yet by being derived from them, it is still commonly associated with this class).


Sunifiram has mechanisms similar to Nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Its anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile.

 

DOSING of Sunifiram


Like what was mentioned above, the typical dose for an adult human would be approximately 5mg of sunifiram. The strength of the effects are greater when it is taken sublingually (i.e. under the tongue) as opposed to just swallowing it. Don't worry too much if you go over the standard dose, though! Sunifiram has extremely low toxicity and a huge range between therapeutic and dangerous amounts.


Sunifiram Function:

 

Sunifiram increases energy levels, allowing users to feel more motivated and eliminate

 

Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli

 

Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.

 

Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.


 


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