Healthy Female Bodybuilding Hormone Powder Progesterone (57-83-0)

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Name:Chlormadinone acetate 

Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione

CAS: 302-22-7 

MF: C23H29ClO4

MW: 404.93

Standard: CP2000, JP13 

Appearance: white crystalline powder 

Assay: 99% 

Packing:1kg/Foil bag

Pharmaceutical intermediates; Steroid and Hormone; Carbonyl compounds; Steroid hormones (hormones, glucocorticoids); SUICALM; Pharmaceutical intermediates; Hormone research API; Steroid hormones; Pharmaceutical raw materials; Small molecule inhibitors.

Usage: Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal).

Reference FOB Price:$1/g

MOQ:10g

Specification:ISO9001,USP,BP,GMP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shipping: DHL, EMS, FedEx, UPS

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Chlormadinone Acetate Powder Description:

Chlormadinone acetate (CMA) is a derivative of naturally secreted progesterone that shows high affinity and activity at the progesterone receptor.

It has an anti-estrogenic effect and, in contrast to natural progesterone, shows moderate anti-androgenic properties. CMA acts by blocking androgen receptors in target organs andby reducing the activity of skin 5alpha-reductase.

It suppresses gonadotropin secretion and thereby reduces ovarian and adrenal androgen production.

CMA shows high contraceptive efficacy by inhibiting ovulation due to its ability to suppress or disrupt endogenous gonadotropin secretion and, by this, inhibits follicular growth and maturation. In addition, it suppresses endometrial thickness and increases the viscosity of cervical mucus.

The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.

Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients.

The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.

Chlormadinone Acetate Powder Applications:

Chlormadinone acetate , sometimes abbreviated as CMA, is a steroidal progestin with additional antiandrogen and antigonadotropic (and thus also antiestrogenic) effects.

It is used clinically as a hormonal contraceptive, and in part due to its lowering of estrogen levels, but also for improved effectiveness in contraception, chlormadinone is frequently combined with ethinyl estradiol for this purpose. It is the acetate ester of chlormadinone.