Duloxetine API Anti-Depressant and Analgesic 136434-34-9 Duloxetine Hydrochloride

Basic Info.

Product Name:Duloxetine hydrochloride

Synonyms:(S)-DULOXETINE HYDROCHLORIDE;LY-248686;DULOXETINE HCL;DULOXETINE HYDROCHLORIDE;N-methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine, hydrochloride;(RS)Duloxetine HCl;(+)-(S)-N-Methyl-g-(1-naphthyloxy)-2-thiophenepropylamine;(gS)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine

CAS:136434-34-9

MF:C18H20ClNOS

MW:333.88

EINECS:200-659-6

Chemical Properties:White Crystalline Solid

Purity:99%

Usage:Labelled Duloxetine, which is used as an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Current lot is 97% d7 with no d0, d1 or d2

Usage:An antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.

Usage:leucotriene antagonist, antiasthmatic

Usage:anti-depressant, analgesic for osteoarthiritis and musculoskeletal pain

Usage:solubility H2O: soluble5 mg/mL (clear solution, warmed)

Reference FOB Price:$0.85/g

MOQ:1kg

Specification:ISO9001,USP,BP,GMP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shipping: DHL, EMS, FedEx, UPS

Payment: Western Union, Moneygram, T/T, Bitcoin

Delivery time: Parcel can be sent out within 24hours after your payment, 4~7 days to arrive.

More details pls contact:Whatapp:86 13048470428

 Skype/E-mail : summer at chembj.com

Product Description:

1Duloxetine, sold under the brand name Cymbalta among others, is a serotonin-norepinephrine reuptake inhibitor (SNRI) created by Eli Lilly. It is mostly prescribed for major depressive disorder, generalized anxiety disorder, fibromyalgia and neuropathic pain.

2.Duloxetine failed to receive US approval for stress urinary incontinence amid concerns over liver toxicity and suicidal events; however, it was approved for this indication in the UK, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery.

COA

Items of analysis Specification Results

Description White or off- white crystalline powder White crystalline powder

Loss on drying (%) Not more than 0.5% 0.2%

Melting Point 160.0~165.0ºC 162.7~163.3

Specific Rotation +115.0~+125.0° +117.8°

Heavy metals ≤0.001% <0.001%

Purity(HPLC) Single impurity≤0.5% 0.2%

Assay by HPLC(A%) Not less than 98.0% 99.5%

Conclusion Qualified

Duloxetine hydrochloride-----Application

1.The main uses of duloxetine are in major depressive disorder, generalized anxiety disorder, urinary incontinence, neuropathic pain, chronic musculoskeletal pain, and fibromyalgia.

2.Duloxetine is recommended as a first line agent for the treatment of chemotherapy-induced neuropathy by the American Society for Clinical Oncology, as a first-line therapy for fibromyalgia in the presence of mood disorders by the German Interdisciplinary Association for Pain therapy, as a Grade B recommendation for the treatment of diabetic neuropathy by the American Association for Neurology and as a level A recommendation in certain neuropathic states by the European Federation of Neurological Societies.

3.A 2014 Cochrane review concluded that duloxetine is beneficial in the treatment of diabetic neuropathy and fibromyalgia but that more comparative studies with other medicines are needed. The medical journal Prescrire (based in France) concluded that duloxetine is no better than other available agents and has a greater risk of side effects. Thus they recommend against its general use.