99% CAS 55079-83-9 Acitretin/Etretin for Resistant-Psoriasis-Treatment

Basic Info.

Product: Acitretin

Category: A synthetic retinoid

CAS:55079-83-9

MF: C21H26O3

MW:326.43

EINECS:259-474-4

Character: Yellow or light orange crystalline powder

MP: 228-230°C

Assay: 99%min

Purity: green-yellow powder

storage temp: 2-8°C

Package: 100G/500G/1KG/bag

Description: A synthetic retinoid which is the major metabolite of etretinate (E938000).

Reference FOB Price:$2.66/g

MOQ:10g

Specification:ISO9001,USP,BP,GMP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shipping: DHL, EMS, FedEx, UPS

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Brief Introdution of Acitretin

Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.

It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.

Medical Application of Acitretin

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in 

only very severe cases of psoriasis that have been  unresponsive to other treatments.

It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cellreproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.

Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.

Adverse effect:

Acitretin is noted for the possibility of severe birth defects and should not be used by pregnant women or women planning to get pregnant within 3 years following the use of acitretin. Sexually active women of childbearing age  who use acitretin should also use at least 2 forms of birth control concurrently. Men and women who use it should not donate blood for 3 years after

 using it, because of the possibility that the blood might be used in a pregnant patient and cause birth defects.

In addition,it may cause nausea, headache, itching, dry, red or flaky skin, dry or red eyes, dry or chapped lips, swollen lips, dry mouth, thirst, 

cystitis acne or hair loss.