Roflumilast CAS 162401-32-3 for the prevention and treatment of respiratory disease

Profile

Product Name: Roflumilast

Synonyms: ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

CAS: 162401-32-3

MF: C17H14Cl2F2N2O3

MW: 403.21

Purity: 99.5%min

Appearance: White or almost white crystalline powder

Description

Roflumilast is a kind of oral and selective phosphodiesterase IV (PDE4) inhibitors. It is benzamides compound. And it is the only approved oral phosphatase IV (PDE-4) inhibitors that used in the treatment of respiratory diseases currently. It can selectively inhibit PDE4, block the signal transduction of inflammation, and then inhibit the damage to lung tissue caused by respiratory diseases such as COPD and asthma. It has proven to be a new mode of action in inhibiting COPD related-inflammation. Roflumilast is a once-daily tablet, and the first new type of drug for the treatment of severe COPD. It is also the first oral anti-inflammatory drugs for patients with COPD. Its unique nature can facilitate the better management of chronic obstructive pulmonary patients: when the combination with bronchodilator in the treatment of the most severe chronic obstructive pulmonary patients, roflumilast can offer the additional benefits of further reducing the symptoms and disease progression rates. Then it became the first drug of targeting particular phenotype of chronic obstructive pulmonary disease that is patients with severe airflow limitation and having a history of recurrent disease worsening associated with chronic cough and sputum.

Application

Roflumilast can be used for the prevention and treatment of respiratory disease, and used for the treatment of severe chronic obstructive pulmonary disease (COPD) and excessive mucus cough bronchitis, asthmatic bronchitis, bronchial asthma, respiratory tract associated with abnormal secretion of acute and chronic bronchitis, air sacculitis, etc. 

Chronic obstructive pulmonary disease (referred to as "COPD"), is chronic lung disease that characterized by incompletely reversible airflow obstruction. It is usually manifested clinically recurrent cough, sputum, dyspnea and other symptoms. That usually shows progressive progress features, including the vast majority of chronic bronchitis and emphysema. As the disease progresses, it will lead to airway remodeling, and ultimately develop to irreversible airflow obstruction, or coexist with asthma overlap. Therefore, improving the control of airflow obstruction and inflammation is the main goal of drug research at home and abroad.