Dexamethasone 21-phosphate disodium salt CAS 2392-39-4  

Product Name: Dexamethasone 21-phosphate disodium salt

Synonyms: decadronphosphate;dexadreson;dexagro;dexamethasonedisodiumphosphate;disodiumdexamethasonephosphate;disodiumsalt,(11beta,16alpha)-y);megacort;pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox

CAS: 2392-39-4

MF: C22H28FNa2O8P

MW: 516.4

EINECS: 219-243-0

Product Categories: Immunomodulators and AntibioticsLipids;Steroids (C21) and Derivatives;Immune Cell Signaling and Blood;Immune System Regulation;Sterols;Pharmaceutical intermediate;API;HEXADROL;Hormone Drugs

Mol File: 2392-39-4.mol

Usage：glucocorticoid, antiinflammatory

Dexamethasone Sodium Phosphate is a systemic corticosteroid. Dexamethasone Sodium Phosphate induces apoptosis and inhibits sodium phosphate symporter. Dexamethasone Sodium Phosphate is also used in the treatment of emetic effects of cancer therapy and epicondylitis. Dexamethasone Sodium Phosphate is an activator of GR.

Adrenal corticosteroids. With anti-inflammatory, anti-allergic, anti-rheumatic, immunosuppressive effects, the mechanism of action:

(1) anti-inflammatory effect: the goods to reduce and prevent the organization's response to inflammation, thereby reducing the performance of inflammation. Can inhibit the inflammatory cells, including macrophages and leukocytes in the inflammatory site of aggregation, and inhibition of phagocytosis, lysosomal enzyme release and inflammatory chemical synthesis and release of intermediates.

(2) immunosuppressive effects: including the prevention or inhibition of cell-mediated immune response, delayed hypersensitivity, reduce T lymphocytes, monocytes, the number of acidophage cells, reducing the immunoglobulin and cell surface receptor binding And inhibit the synthesis and release of interleukin, thereby reducing the transformation of T lymphocytes into lymphoblasts, and reduce the situation of primary immune response expansion. This product also reduces the immune complexes through the basement membrane, and can reduce complement components and immunoglobulin concentration.