Local Anesthetic Drugs Articaine Hydrochloride CAS 23964-57-0  for Pain Control

Articaine hydrochloride Profile

Product Name:Articaine hydrochloride

CAS NO. : 23964-57-0 

EINECS : 245-957-7

MF : C13H21ClN2O3S

MW : 320.84

Purity : 98%

Appearance : White powder

Storage: Shading, Closed preservation

Delivery time : Within 24 hours upon receipt of payment

Shipment : EMS, DHL, TNT, FedEx, UPS

Usage : Pain Control,a topical anesthetic for oral cavity and is particularly suitable for use in surgical procedures involving osteotomy and mucosal incision

Pharmacology and toxicology

Atenicol hydrochloride is an amide local injection of anesthetic, can block the nerve fibers along the injection site nerve conduction, from the local anesthetic effect. Addition of 1 / 100,000 adrenaline to the solution in the solution is to contract the local blood vessels, delay the anesthetic into the systemic circulation, maintain the local tissue concentration, and also obtain the surgical field with very little bleeding. The effect of local anesthesia occurs 2-3 minutes after administration and lasts about 60 minutes. Pulp anesthesia, can be shortened 2-3 times.

Pharmacokinetics

Hydrochlorothiazin buccal mucosa injection 30 minutes, the peak plasma concentration; hydrochloric acid to eliminate the half-life of about 110 minutes of articaine; hydrochloric acid mainly by the liver metabolism of phthalate; 5% -10% of the dose of drugs to prototype From the urine.

Indications

Oral topical anesthetics are particularly suitable for use in surgical procedures involving osteotomy and mucosal incision.

Usage and dosage

Local infiltration or nerve block anesthesia, oral submucosal injection. Before pumping the blood back to check whether the blood vessels, especially nerve block anesthesia. The injection rate should not exceed 1 ml / min. Adults: The appropriate dose must be administered according to the needs of the operation. For general surgery, usually given dose of 1/2 to 1 or compliance. The maximum dose of articaine hydrochloride should not exceed 7 mg / kg body weight. Children over 4 years of age: different doses must be used depending on the age, weight, and type of operation of the child. The maximum dose of articaine hydrochloride does not exceed 5 mg / kg body weight. The average dose for children receiving orally taking orally is calculated in milligrams as follows: Weight of child (kg) x1.33 Older: Half of adult dose.