Ranitidine hydrochloride CAS 71130-06-8 for Treat of  Peptic Ulcer Disease 

Quick Details 

Name: Ranitidine hydrochloride

Synonym: N-[2-[[5-[(dimethylamino)methyl]furfuryl]thio]ethyl]-N'-methyl-2-nitrovinylidenediamine monohydrochloride, Ranitidine hcl; (E)-N-{2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitroethene-1, 1-diamine hydrochloride; Ranitidine Hydrochlooride; Noctone

CAS: 71130-06-8

EINECS: 275-207-4

Assay: 99%

M. F: C13H22N4O3S· HCl

M. W: 350.86

Density: G/cm3

Appearance: A kind of white or pale yellow crystalline powder, odor, taste slightly bitter with acerbity, easy deliquescence, moisture absorption after dark

Application: To reduce the secretion of gastric acid, promote ulcer healing.

Package: 20KG/cardboard drum

Price:negotiable 

MOQ:10g

Specification:ISO9001,USP,BP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shipping: DHL, EMS, FedEx, UPS

Shelf life:2 years

More details pls contact:Whatapp:86 13048470428  

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Description

Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production. It is commonly used in treatment of peptic ulcer disease,gastroesophageal reflux disease, and Zollinger-Ellison syndrome. There is also tentative evidence of benefit forhives. It can be taken by mouth, by injection into a muscle, orinto a vein.

Medical Usage:

1. Relief of heartburn;

2. Short-term and maintenance therapy of gastric and duodenal ulcers;

3. Ranitidine can also be given with NSAIDs to reduce the risk of ulceration. Proton-pump inhibitors (PPIs) are more effective for the prevention of NSAID-induced ulcers;

4. Pathologic gastrointestinal (GI) hypersecretory conditions such as Zollinger-Ellison syndrome;

5. Gastroesophageal reflux disease (GERD);

5. Erosive esophagitis;

6. Part of a multidrug regimen for Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence;

7. Recurrent postoperative ulcer;

8. Upper GI bleeding;

9. Prevention of acid-aspiration pneumonitis during surgery: ranitidine can be administered preoperatively to reduce the risk of aspiration pneumonia. The drug not only increases gastric pH, but also reduces the total output of gastric juice. In a 2009 meta-analysis comparing the net benefit of proton pump inhibitors and ranitidine to reduce the risk of aspiration before anesthesia, ranitidine was found to be more effective than proton pump inhibitors in reducing the volume of gastric secretions.Ranitidine may have an antiemetic effect when administered preoperatively;

10. Prevention of stress-induced ulcers in critically ill patients.

COA

Items of analysis Specification Results

Appearance, color White to light yellow crystalline powder; odor; taste bitter with astringent; easy deliquescence, moisture absorption after dark Conforms

Solubility Soluble in water, very slightly soluble in ethanol, almost insoluble in ether Conforms

Identification Whater liquor show chloride Conforms

Clarity and color Should Compliance Conforms

PH 4.5-6.5 Conforms

Related compounds ≤0.5% 0.01%

Single impurity ≤0.2% 0.04%

Total impurity ≤0.5% 0.2%

Loss on drying ≤0.75% 0.25%

Residue on ignition ≤0.1% 0.06%

Heavy metal ≤20ppm Conforms

Assay 97.5-102% 99.72%

Conclusion Qualified