Factory Directly Supply 99% Idebenone CAS No:58186-27-9

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Product name:Idebenone

Other name:Idebenone

CAS No:58186-27-9

Molecular formula:C19H30O5

Molecular weight:338.44

EINECS:N/A

Assay:99% min pure

Appearance: orange-yellow crystalline powder

Catalogue:Pharmaceutical materials;Health supplements;APIs;Brain health drug;Nootropic

Other Nootropics we offer:noopept;hydroxypiracetam;piracetam;Ferulic Acid;COLURACETAM

Usage:Used for cerebral infarction, cerebral hemorrhage and cerebral artery sclerosis associated with depression, such as language barriers and intelligence impairment, etc.

Standard:Enterprise Standard 

Price:negotiable 

MOQ:10g

Specification:ISO9001,USP,BP

Trade Mark:CQSP

Port:Shanghai,China

Production Capacity:5000kg/month

Inspection: SGS, ISO9001

Shipping: DHL, EMS, FedEx, UPS

More details pls contact:Whatapp:86 13048470428 

Skype/E-mail : summer at chembj.com

What is Idebenone?

Idebenone (pronounced eye-deb-eh-known, trade names Catena, Raxone, Sovrima, among others) is a drug that was initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects.This has been met with limited success. The Swiss company Santhera Pharmaceuticals has started to investigate it for the treatment of neuromuscular diseases

Idebenone are used for:

Nootropic effects and Alzheimer's disease

Idebenone improved learning and memory in experiments with mice.In humans, evaluation of Surrogate endpoints like electroretinography, auditory evoked potentials and visual analogue scales also suggested positive nootropic effects, but larger studies with hard endpoints are missing.

Friedreich's ataxia (Sovrima)

Preliminary testing has been done in humans and found idebenone to be a safe treatment for Friedreich's ataxia (FA), exhibiting a positive effect on cardiac hypertrophy and neurological function.The latter was only significantly improved in young patients.[9] In a different experiment, a one-year test on eight patients, idebenone reduced the rate of deterioration of cardiac function, but without halting the progression of ataxia.

Other neuromuscular diseases

Phase I and II clinical trials for the treatment of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) and primary progressive multiple sclerosis are ongoing as of December 2013.

Pharmacokinetics of Idebenone

Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This rate can be improved with special formulations (suspensions) of idebenone and by administering it together with fat food; but even taking these measures bioavailability still seems to be considerably less than 14% in humans. More than 99% of the circulating drug are bound to plasma proteins. Idebenone metabolites include glucuronides and sulfates, which are mainly (~80%) excreted via the urine.

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