Naloxone hydrochloride 357-08-4  Injection Rescue acute ethanol poisoning

Naloxone hydrochloride Profile

CAS No. 357-08-4 

Chemical Name: Naloxone hydrochloride 

Synonyms: en1530;narcan;Nalone;nalonee;nih7890;EN-15304;Narcanti;NALOXONE HCL;NALOXONE HYDROCHLORIDE;l-Naloxone hydrochloride 

Molecular Formula: C19H22ClNO4 

Formula Weight: 363.84 

MOL File: 357-08-4.mol 

Appearance: white crystalline or crystalline powder; odorless.

nature: soluble in water, dissolved in methanol, almost insoluble in chloroform or ether.

rotation :  -170 °to -181 °.

Purity:99%

Package:25kg/barrel or as your inquiry 

Shelf life:2 years

Standard:Enterprise Standard 

Price:negotiable 

MOQ:10g

Specification:ISO9001,USP,BP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shipping: FedEx, DHL, EMS, TNT, HK EMS, Eub, Etk

Payment: Western Union, Moneygram, T/T, Bitcoin

Delivery time: Parcel can be sent out within 24 hours after payment,4-7days to arrive.

Naloxone hydrochloride Indications 

This product is opioid receptor antagonist.

1. For opioid compound anesthesia, antagonism of the drug-induced respiratory depression, prompting the patient to wake up.

2. For opioid overdose, complete or partial reversal of opioid-induced respiratory depression.

3. Rescue acute ethanol poisoning.

4. For the diagnosis of acute opioid overdose.

Adult use

Opioid overdose can be injected intravenously for the first time in this product 0.4mg-2mg, if not obtained the ideal function of respiratory function and improvement, can be separated from 2 to 3 minutes repeated injection. If you do not respond to 10mg, you should consider this diagnosis. If intravenous administration is not possible, intramuscular administration.

Postoperative opioid inhibition partially corrects the opioid inhibitory effect of opioid use after surgery. The dosage of this product should be determined according to the patient's response. For the first time to correct respiratory inhibition, every 2 to 3 minutes, intravenous injection of 0.1mg ~ 0.2mg, until the desired effect, that is, the patency of the respiratory and awake, no obvious pain and discomfort. More than the necessary dose of this product can significantly reverse the pain and hypertension. Likewise, the reversal is too rapid to cause nausea, vomiting, sweating, or cyclic burden.

The amount of the product to be repeated within 1 to 2 hours interval depends on the dosage of the last opioid used, the type of Administration (short acting or long acting), and the interval time.

Severe alcohol poisoning 0.8 ~ 1.2mg, one hour after repeated administration of drugs from 0.4 to 0.8mg.

Children use

Opioid overdose of intravenous injection of the first dose of 0.01mg/ kg,. If this dose does not have a satisfactory clinical effect, then it should be given to 0.1mg/kg. If you can not intravenous injection, intramuscular injection can be divided. If necessary, Sterile Water for Injection can dilute the product.

Recommendations and considerations for postoperative opioid suppression effects in adult patients with opioid suppression. For the first time to correct respiratory inhibition effect, every 2 ~ 3 minutes of intravenous injection of this product is 0.005 mg ~ 0.01mg, until the desired degree of reversal.

Neonatal medication:

Inhibition of opioid induced static common initial dose injection, intramuscular or subcutaneous injection of 0.01mg per kg of body weight. The dose can be repeated in accordance with the postoperative opioid inhibition in adults.

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